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Synthesis of 4-(3-Hydroxyalkyl)pyrimidines by Ring Transformation Reactions of 2-Alkylidenetetrahydrofurans with Amidines.

✍ Scribed by Esen Bellur; Peter Langer

Publisher
John Wiley and Sons
Year
2006
Weight
35 KB
Volume
37
Category
Article
ISSN
0931-7597

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Synthesis of Chiral 4-(Ο‰-Hydroxyalkyl)pyrazolidin-3-ones by Ring-Chain Transformation of Ξ±-Alkylidenelactones with Hydrazines. -This is the first access to optically active 4-(Ο‰-hydroxyalkyl)pyrazolidin-3-ones. The lactone (IX), however, cannot be transformed into the corresponding pyrazolidinone.