Three d e u t e r i u m l a b e l l e d drugs, 5-ethyl-d,-5-phenylthiobarbit u r i c a c i d , p r i m i d o n e -e t h y l -L 5 , and p h e n o b a r b i t a l -e t h y l -d 5 , have been p r e p a r e d employing a t h r e e s t e p s y n t h e s i s u t i l i z i n g d i e t h y l phenylmalonate
Synthesis of 2-ethyl-2-phenyl-d5-glutarimide (glutethimide-d5)
โ Scribed by Hassan Y. Aboul-Enein
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- French
- Weight
- 155 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
The synthesis of 2โethylโ2โphenylโd~5~โglutarimide (glutethimideโd~5~) and its mass fragmentometry is described.
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The drug 5-phenyl-5-phenyl -d -hydantoin was prepared employing a f i v e step synthesis starting%m readily available benzene-&. Two key intermediates, benzoin-d , and benzil-&, were prepared, containing only one f u l l y l a b e d d phenyl-d group. The precursor benzll-d was condensed w i t h ure
## Abstract The synthesis of deuterated ethanolamines and deuterated 2โdicyclopropylmethylamineโฮ^2^โoxazolines is described.