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A synthesis of 5-phenyl-d5-phenyl-d5-hydantoin

✍ Scribed by Brian D. Andresen; K. Biemann

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
368 KB
Volume
15
Category
Article
ISSN
0022-2135

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✦ Synopsis

The drug 5-phenyl-5-phenyl -d -hydantoin was prepared employing a f i v e step synthesis starting%m readily available benzene-&.

Two key intermediates, benzoin-d , and benzil-&, were prepared, containing only one f u l l y l a b e d d phenyl-d group. The precursor benzll-d was condensed w i t h urea t o generde the labelled drug, dipheny4ydantoin-3. This new probe possesses only one f u l l y labelled phenyl group making i t suitable f o r metabolic studies and as an internal standard f o r c d i n e d GC-MS-conputer analyses o f body f l u i d extracts. Synthetic procedures as well as complete spectral data o f precursors and the labelled drug are presented.

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