Synthesis of 5-ethyl-d5-5-phenyl-2-thioxobarbituric acid, primidone-ethyl-d5 and phenobarbital-ethyl-d5

✍ Scribed by Brian D. Andresen; K. Biemann

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: French
• Weight: 298 KB
• Volume: 16
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580160505

✦ Synopsis

Three d e u t e r i u m l a b e l l e d drugs, 5-ethyl-d,-5-phenylthiobarbit u r i c a c i d , p r i m i d o n e -e t h y l -L 5 , and p h e n o b a r b i t a l -e t h y l -d 5 , have been p r e p a r e d employing a t h r e e s t e p s y n t h e s i s u t i l i z i n g d i e t h y l phenylmalonate and bromoethane-Cs. O v e r a l l i s o t o p i c p u r i t y o f t h e l a b e l l e d drugs was i n excess o f 95':. Complete s y n t h e t i c techniques as w e l l as s p e c t r a l d a t a of l a b e l l e d i n t e rmediate and drugs a r e presented.