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Synthesis of 2-chloroethyl (13C)-methyl sulfide

✍ Scribed by Douglass F. Taber; Robert P. Meagley

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
142 KB
Volume
31
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Incorporation of a stable isotope‐labelled methylthio group into the mustard 2‐chloroethyl methyl sulfide 2 was complicated by concomitant reaction with iodide ion, a necessary byproduct from the precursor stable isotope‐labelled iodomethane. A two step procedure was therefore employed, initial displacement with mercaptoethanol 4 being followed by chlorination with thionyl chloride.

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