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Synthesis of 2-Chirally Substituted 3,3′-Biquinazoline-4,4′-diones

✍ Scribed by Pertusati, Fabrizio; Coogan, Michael P.

Book ID
121807688
Publisher
Journal of Heterocyclic Chemistry
Year
2014
Tongue
English
Weight
818 KB
Volume
51
Category
Article
ISSN
0022-152X

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ChemInform Abstract: Solid-Phase Synthes
ChemInform Abstract: Solid-Phase Synthesis of Chiral 3-Substituted Quinazoline-2,4-diones.
✍ L. GOUILLEUX; J.-A. FEHRENTZ; F. WINTERNITZ; J. MARTINEZ 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

Solid-Phase Synthesis of Chiral 3-Substituted Quinazoline-2,4-diones. -A series of N-urethane precursors such as (I) or (III) are prepared and subjected to cyclization in the presence of base (DBU, NaOH or NEt3). The desired quinazolines are obtained in good to excellent yield without racemization.