Synthesis of 2- and 3-substituted-1,2,3,4-tetrahydrodibenzo[f,h]isoquinolines
✍ Scribed by Mercedes T. Grande; Gregorio G. Trigo; Mónica M. Söllhuber
- Book ID
- 112128257
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1986
- Tongue
- English
- Weight
- 358 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-152X
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📜 SIMILAR VOLUMES
An Efficient Synthesis of 6-Substituted 2-(2H-[1,2,4]Triazol-3ylmethyl)-1,2,3,4-tetrahydro-isoquinolines. -Using a bis-alkylation of amine (V) with mesylate (VI) as the key step, title compounds such as (VII)-(IX) are easily prepared. The structure of compound (IV) is proven by X-ray analysis. -(UR
## Abstract The intramolecular cyclization of 2‐acylphenylacetonitriles **1** under strongly acidic conditions easily affords 1‐substituted 2__H__‐isoquinolin‐3‐ones **2** in excellent yields.
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