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ChemInform Abstract: An Efficient Synthesis of 6-Substituted 2-(2H-[1,2,4]Triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolines.

✍ Scribed by Frank J. Urban; Ralph Breitenbach

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

An Efficient Synthesis of 6-Substituted 2-(2H-[1,2,4]Triazol-3ylmethyl)-1,2,3,4-tetrahydro-isoquinolines.

-Using a bis-alkylation of amine (V) with mesylate (VI) as the key step, title compounds such as (VII)-(IX) are easily prepared. The structure of compound (IV) is proven by X-ray analysis. -(URBAN,

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