✦ LIBER ✦

A novel synthesis of 1-substituted 2H-isoquinolin-3-ones

✍ Scribed by Alicia S. Cánepa; Rodolfo D. Bravo

Publisher: Journal of Heterocyclic Chemistry
Year: 2004
Tongue: English
Weight: 36 KB
Volume: 41
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570410620

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✦ Synopsis

Abstract

The intramolecular cyclization of 2‐acylphenylacetonitriles 1 under strongly acidic conditions easily affords 1‐substituted 2__H__‐isoquinolin‐3‐ones 2 in excellent yields.

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## Abstract Isoquinolinones were brominated using __N__‐bromosuccinimide in dimethylformamide at room temperature to give 4‐bromo‐3‐substituted isoquinolin‐1‐(2__H__)‐ones. The reaction of these isoquinolinones with propargyl bromide in the presence of anhydrous potassium carbonate yielded __N__ an

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ChemInform Abstract: Reaction of 3-Subst

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