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Reaction of 3-substituted and 4-bromo-3-substituted isoquinolin-1-(2h)-ones with propargyl bromide

✍ Scribed by Cyril Odianose Usifoh

Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
39 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Isoquinolinones were brominated using N‐bromosuccinimide in dimethylformamide at room temperature to give 4‐bromo‐3‐substituted isoquinolin‐1‐(2__H__)‐ones. The reaction of these isoquinolinones with propargyl bromide in the presence of anhydrous potassium carbonate yielded N and O‐alkylated products.

📜 SIMILAR VOLUMES

A novel synthesis of 1-substituted 2H-is
A novel synthesis of 1-substituted 2H-isoquinolin-3-ones
✍ Alicia S. Cánepa; Rodolfo D. Bravo 📂 Article 📅 2004 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 36 KB

## Abstract The intramolecular cyclization of 2‐acylphenylacetonitriles **1** under strongly acidic conditions easily affords 1‐substituted 2__H__‐isoquinolin‐3‐ones **2** in excellent yields.