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Synthesis of 2-Amino-5-sulfanyl-1,3,4-thiadiazole Derivatives and Evaluation of Their Antidepressant and Anxiolytic Activity

✍ Scribed by Clerici, Francesca; Pocar, Donato; Guido, Maddalena; Loche, Antonella; Perlini, Vincenzo; Brufani, Mario


Book ID
118047360
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
99 KB
Volume
44
Category
Article
ISSN
0022-2623

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## Abstract The reaction of 3‐(dicyanomethylene)‐2‐indolone in a solution of ethanol/piperidine with 4‐substituted thiosemicarbazides forms the derivatives of 5′‐(substituted amino)‐3β€²__H__–spiro(indoline‐3,2′‐[1,3,4]thiadiazol‐2‐one. Rationales for these conversions involving the nucleophilic addi