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Synthesis and evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazoles as antidepressant, anxiolytic, and anticonvulsant agents

✍ Scribed by Priyabrata Pattanayak; Rajesh Sharma; Prasanta Kumar Sahoo


Book ID
105770901
Publisher
Springer-Verlag
Year
2008
Tongue
English
Weight
282 KB
Volume
18
Category
Article
ISSN
1054-2523

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## Abstract The reaction of 3‐(dicyanomethylene)‐2‐indolone in a solution of ethanol/piperidine with 4‐substituted thiosemicarbazides forms the derivatives of 5′‐(substituted amino)‐3β€²__H__–spiro(indoline‐3,2′‐[1,3,4]thiadiazol‐2‐one. Rationales for these conversions involving the nucleophilic addi