Synthesis of [19-11C]arachidonic acid

✍ Scribed by Tor Kihlberg; Bengt Långström

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: French
• Weight: 496 KB
• Volume: 34
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580340705

✦ Synopsis

Abstract

The preparation of (all Z)‐1,17‐dichloro‐4,7,10,13‐heptadecatetraene is reported. The synthesis was performed in five steps with a total yield of 22 %, starting from 5‐chloro‐1‐pentyne. The corresponding bis Grignard reagent was used in a copper‐mediated coupling reaction with [1‐^11^C]ethyl iodide followed by a carbonation with CO~2~ to afford [19‐^11^C]arachidonic acid in 23 % decay corrected radiochemical yield within 52 min. The radiochemical purity of the final product was 98 %. In a typical run starting with 20 GBq [^11^C]O~2~, 760 MBq of [19‐^11^C]arachidonic acid was obtained, with a specific activity of 1.6 GBq/μmol.