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Synthesis of [18F]fluoro-labeled progestins for PET

โœ Scribed by Tjibbe J. De Groot; Aalt Verhagen; Philip H. Elsinga; Willem Vaalburg

Book ID
103922605
Publisher
Elsevier Science
Year
1991
Weight
407 KB
Volume
42
Category
Article
ISSN
0883-2889

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โœฆ Synopsis

The synthesis of 21-[18F]fluoro-16 alpha-methyl-19-norprogesterone, 21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone, 21-[18F]fluoro-16 alpha-methylprogesterone and 21-[18F]fluoro-16 alpha-ethylprogesterone is described. These compounds are prepared with a specific activity greater than 200 TBq/mmol (5000 Ci/mmol) from the corresponding tosylates in 10% radiochemical yield (EOB). A remote controlled system has been developed for this synthesis.

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