## Abstract After successfully synthesizing 16__α__‐[^18^F]fluoroestradiol‐3,17__β__‐disulphamate in an automatic procedure, we studied the conditions for obtaining 16__α__‐[^18^F]fluoroestradiol‐monosulphamates in a similar manner. The described procedure can simultaneously provide approximately 3
Synthesis of 16α-[18F]fluoroestradiol-3,17β-disulphamate
✍ Scribed by J. Römer; F. Füchtner; J. Steinbach
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 401 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-2135
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Although the reported synthesis of the title compound resulted in a high radiochemical yield (43% based on resolubilized 18F), the effective specific activity at EOS was low (166 Ci/mmol). Reduction in the amount of carrier fluoride in the target water improved the effective specific activity of the
16α‐[^18^F]Fluoroestradiol (16α‐[^18^F]FES, 1) is known as a valuable tracer in molecular imaging as estrogen receptor (ER) ligand for investigation of primary and metastatic breast cancer. ER concentration in human breast tumor cells is a significant indicator for the degree of disease and is often