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Simultaneous preparation of 16α-[18F]fluoroestradiol-sulphamates in an automated module. A high-yield procedure for 16α-[18F]fluoroestradiol-17β-sulphamate

✍ Scribed by J. Römer; F. Füchtner; J. Steinbach; H. Kasch

Publisher: John Wiley and Sons
Year: 2001
Tongue: French
Weight: 119 KB
Volume: 44
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.480

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✦ Synopsis

Abstract

After successfully synthesizing 16__α__‐[^18^F]fluoroestradiol‐3,17__β__‐disulphamate in an automatic procedure, we studied the conditions for obtaining 16__α__‐[^18^F]fluoroestradiol‐monosulphamates in a similar manner. The described procedure can simultaneously provide approximately 3 GBq of 16__α__‐[^18^F]fluoroestradiol‐3‐sulphamate and 1 GBq of 16__α__‐[^18^F]fluoroestradiol‐17__β__‐sulphamate of high radiochemical purity. By treating 16__α__‐[^18^F]fluoroestradiol‐3,17__β__‐disulphamate with Kryptofix 2.2.2 and potassium carbonate, 16__α__‐[^18^F]fluoroestradiol‐17__β__‐sulphamate also becomes available at high radioactivity. Copyright © 2001 John Wiley & Sons, Ltd.

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