Synthesis of 15α-hydroxyestrogen 15-N-acetylglucosaminides
✍ Scribed by Emako Suzuki; Susumu Namba; Hiroyuki Kurihara; Junichi Goto; Yasuhiko Matsuki; Toshio Nambara
- Book ID
- 116065867
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 632 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0039-128X
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## S u in ma r y 1sN.15N-imidazoleacetic acid was synthesized from 15N, lSN-DL-histidine (>99 atom % 15N). The latter. oxidized with sodium hypochlorite. formed 15N.15N-imidazoleacetoniuile. The free acid was prepared after acid hydrolysis of the nitrile, elution from an anion exchange column with
Coniine-15N was obtained by the reductive amination of 5-0x0octanal using sodium cyanoborohydride and a m m o n i ~m -~~N bromide. Nornicotine-l'-15N resulted from a similar reductive aminution of 4-oxo-4-(3'-pyridyl)butanal. Merhybtion with formaldehyde and ,formic acid afforded n i ~o t i n e -I '