Synthesis of 14C-labelled metoprolol

Synthesis of 14C-labelled satigrel

✍ Shigeru Tanaka; Youji Yamagishi; Kazutomi Kusano; Tsutomu Yoshimura 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 222 KB 👁 1 views

14C-Labelled satigrel, or 4-cyano-5-(4'-methoxy tring-U-14CI phenyl)-5-(4"methoxyphenyl)-4-pentenoic acid was synthesized for drug metabolism and pharmacokinetic studies using 4,4'-diniethoxy [ring-U-W ] benzophenone as the starting material. The radiochemical yield was 10.0%. The specific radioacti

Synthesis of 14C-labelled crotamiton

✍ Naba K. Chaudhuri; Sudhakar V. Potdar; Thomas J. Ball 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 266 KB

The synthesis of 14C-labelled crotamiton, which is a fungicide, an insecticide as well as a scabicide is described. Starting from 2-bromonitrobenzene and Cu14CN, 2-toluidine, labelled with 14C at the methyl group was prepared by the following sequence of reactions : N O ~-C ~H L + -~~C O O H

Synthesis of 14C-labelled aminoguanidine

✍ Theodore W. C. Lo; Paul J. Thornalley 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 208 KB

## Abstract [^14^C]Aminoguanidine was synthesized by the reaction of hydrazine sulphate with barium [^14^C]cyanamide in a one‐step synthesis, and conveniently isolated by crystallization as the bicarbonate salt. The yield was 32%.

Synthesis of 14C-labelled (+)-limonene

✍ K. Noda; T. Matsuda; Y. Ishikura 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 208 KB

## Abstract ^14^C‐labelled (+)‐limonene was conveniently prepared by the Wittig reaction of (+)‐1‐methyl‐4‐acetylcyclohexene with methyl‐^14^C‐triphenylphosphonium iodide.

Synthesis of 14C-labelled milrinone

✍ D. R. Duncan; D. Johnston; R. S. Andrews 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 124 KB

Synthesis of 14C-labelled butoxyethoxyet

Synthesis of 14C-labelled butoxyethoxyethanol

✍ J. B. A. Thijssen; C. G. M. Janssen; W. L. M. Verluyten; J. J. P. Heykants 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 French ⚖ 189 KB

## Department of Drug Metabolism, Janssen Phamceutica Butoxyethoxyethanoll. an organic solvent used as carrier in the levamisole pour-on formulation, was synthesized a Hakosza etherification of l-%labelled brornobutano with mono tetrahydropyranyl (T.H.P.) protected diethylene glycol and subsequent