𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 14-phenylprostaglandins E1, A1 and F2α

✍ Scribed by Robert T. Buckler; David L. Garling

Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
178 KB
Volume
19
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

In searching for prostaglandins of more specific biological activities, we chose to make analogs having a 14-phenyl substitutent. An examination of space-filling molecular models suggested that such a structural transformation might constrain the lower arm of the PG skeleton in a conformation favoring increased interaction between the two arms. Such interaction would reduce the number of possible conformations and perhaps lead to a sharper profile of pharmacological activities. The synthetic route chosen for the E-type prostaglandins I was based on the conjugate addition of the organ0 cuprate III to the known cyclopentenones II. This reaction is known to

📜 SIMILAR VOLUMES

Short synthesis of 6-oxoprostaglandin E1
Short synthesis of 6-oxoprostaglandin E1 and 6-oxoprostaglandin F1α
✍ T. Tanaka; A. Hazato; K. Bannai; N. Okamura; S. Sugiura; K. Manabe; S. Kurozumi; 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 273 KB

El methyl ester was synthesized in a single pot from (R)-4-cbutyldimethylsiloxy-2-cyclopentenone by organocopper conjugate addition with an w side-chain unit, trapping of the resulting enolate with 6-methoxycarbonyl-2-nitrohex-1-ene, and treatment with aqueous titanium (III) trichloride. Hydrolysis

Prostaglandins III - ±11-deoxy-13,14-dih
Prostaglandins III - ±11-deoxy-13,14-dihydroprostaglandin F1α and F1β - a novel synthesis of prostanoic acids
✍ Jehan F. Bagli; Tibor Bogri 📂 Article 📅 1969 🏛 Elsevier Science 🌐 French ⚖ 175 KB

In the past five years different approaches I to the synthesis of the prostanoic acid skeleton have emerged from various laboratories. Some of these led to the synthesis of natural 2 prostaglandins . This communication reports synthesis of some prostanolc acids using a novel approach: the photoaddi