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A comparison of the central actions of prostaglandins A1, E1, E2, F1α, and F2αin the rat

✍ Scribed by Zbigniew M. Poddubiuk


Publisher
Springer
Year
1976
Tongue
English
Weight
571 KB
Volume
50
Category
Article
ISSN
0033-3158

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In searching for prostaglandins of more specific biological activities, we chose to make analogs having a 14-phenyl substitutent. An examination of space-filling molecular models suggested that such a structural transformation might constrain the lower arm of the PG skeleton in a conformation favori