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Short synthesis of 6-oxoprostaglandin E1 and 6-oxoprostaglandin F1α

✍ Scribed by T. Tanaka; A. Hazato; K. Bannai; N. Okamura; S. Sugiura; K. Manabe; S. Kurozumi; M. Suzuki; R. Noyori

Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
273 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis

El methyl ester was synthesized in a single pot from (R)-4-cbutyldimethylsiloxy-2-cyclopentenone by organocopper conjugate addition with an w side-chain unit, trapping of the resulting enolate with 6-methoxycarbonyl-2-nitrohex-1-ene, and treatment with aqueous titanium (III) trichloride. Hydrolysis of the methyl ester was accomplished by porcine liver esterase.

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