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Synthesis of hexadeuterated diethylstilbestrol (E-3,4-DI-(4-hydroxyphenyl) hex-3-ene-1,1,1,6,6,6-2H6)

✍ Scribed by P. J. De Clercq; C. H. Van Peteghem; J. A. Jonckheere; A. P. De Leenheer


Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
359 KB
Volume
21
Category
Article
ISSN
0022-2135

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πŸ“œ SIMILAR VOLUMES


Synthesis of hexadeuterated diethylstilb
✍ Gijsbert Zomer; Henk J. G. M. Derks; Hans Wynberg πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 French βš– 184 KB

d61-E-3,4-di-(4-hydroxyphenyl)-hex-3-ene was s y nt h e s i z e d from [1,?,1-d31-4-methoxypropiophenone by r e d u c t i v e coup l i n g . The p r e p a r a t i o n o f [1,1,1-d31-4-methoxypropiophenone i nv o l v e d r e a c t i o n o f p -a n i s o y l c h l o r i d e w i t h p e r d e u t e r a

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A short and stereoselective synthesis o f hexadeuterated hexest r o l is described, involving catalytic hydrogenation o f -2-3,4-di-(4-methoxyphenyl) hex-3-ene-l , 1,1,6,6,6-H6 followed by demethylation using sodium thioethoxide in dimethyl formamide. 2 KEY WORDS : 'H6-hexestrol, deuterium labellin

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✍ Penelope J. Marshall; Lewis L. Engel πŸ“‚ Article πŸ“… 1975 πŸ› John Wiley and Sons 🌐 French βš– 260 KB

I, I, l-D31 ~-3,4-Di-fI-hydroxyphenyI)-her3-ene has been synthesized from I, 2-di-f4-rnethoxyphenyI)-butan-l-one. Reaction of t h i s ketone w i t h [2,2,2-D3] e t h y l magnesium iodide y i e l d s [ l , l , l-D3]3,4-di-f4-methoxyphenyl)-hexan-3-ol, which on dehydration w i t h potassium hydrogen

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1,1,1,2,2-D, ] E-3,4-Di-(4-hydroxyphenyl) -hex-3-ene has been synthesized from l,l-di-(4-benzyloxyphenyl)-butyraldehyde. The preparation of this aldehyde is described. Its reaction with pentadeuterated ethyl magnesium bromide yields [ 1 , 1 , 1 , 2 , 2-D5] 4,4-d1-(4-benzyloxyphenyl)-hexan-3-01, whic