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Synthesis of 1,4-dihydro-1-methyl-4-oxonicotinonitrile-8-14C

✍ Scribed by H. E. Johnson; G. R. Waller

Publisher
John Wiley and Sons
Year
1968
Tongue
French
Weight
177 KB
Volume
4
Category
Article
ISSN
0022-2135

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✦ Synopsis

The possibility that I ,4-dihydro-I-methyl-4-oxonicotinonitrile ( V ) is an intermediate in the biosynthesis of the alkaloid ricinine from nicotinic or quinolinic acid in Ricinus communis L. led to our interest in preparing the carbon-14 labeled compound. The 4oxonicotinonitrile ( V ) and the corresponding 6-oxonicotinonitrile were shown to be oxidation products of nicotinonitrile methiodide by a crude enzyme preparation from castor seedlings ( 1 , i ) . The 6-oxonicotinonitrile was shown to be identical to the alkaloid nudiflorine isolated,from Trewia nudiflora (3).

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