✦ LIBER ✦

Synthesis of [13N]cisplatin

✍ Scribed by Martin T. Haber; Arthur J. L. Cooper; Karen C. Rosenspire; James Z. Ginos; David A. Rottenberg

Publisher: John Wiley and Sons
Year: 1985
Tongue: French
Weight: 371 KB
Volume: 22
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580220512

No coin nor oath required. For personal study only.

✦ Synopsis

A method for the "carrier-added" synthesis of [ 13N]cisplatin is described.

Yields were -1-4 mCi from 20-40 mCi of ['3N]ammonia with a total synthesis time of 19-28 minutes. The product was -96% radiochemically pure as judged by HPLC analysis and had a specific activity of -100 mCi/mmole in 1 . 0 ml of saline.

[ 13N]Cisplatin was administered intraperitoneally to mice. Of the tissues investigated, concentration of label was highest in kidneys. At 10 min, considerable label in the blood, liver, and kidney was in a form other than cisplatin. However, no evidence was obtained that [ 13N] amonia was released from [13N]cisplatin in vivo. ['3N]Cisplatin may be used to assess drug delivery to primary and metastatic brain tumors in patients receiving intravenous or intraarterial cisplatin chemotherapy.

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