Synthesis of (±)-1,2,4-tri-O-benzyl-myo-inositol
✍ Scribed by Jill Gigg; Roy Gigg; Sheila Payne; Robert Conant
- Book ID
- 107725513
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 172 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0008-6215
No coin nor oath required. For personal study only.
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An improved procedure for the preparation of 1,2-O-isopropylidene-nqVo-inositol is described. Racemic 1,4-di-O-benzyl-2,3-O-isopropylidene-myo-inositol was prepared by tinmediated benzylation of 1,2-0-isopropylidene-myo-inositol and resolved readily by crystalk sation of the o-camphanates. The use o
The synthesis of the optically pure 1,4,5,6-tetra-O-benzyl-myo-inositols was achieved in four steps via diastereomeric 2,3-spire-acetals of myo-inositol with Land D-camphor as the key intermediates. Camphor dimethyl acetal was used for the acetalation reaction. The diastereomers were benzylated and