Synthesis of 1,2- and 1,4-amino alcohols from 1,3-dienes via oxazines. Rearrangements of 1,4-amino alcohol derivatives to oxazolines
โ Scribed by Lukas Werner; Jason Reed Hudlicky; Martina Wernerova; Tomas Hudlicky
- Book ID
- 108283271
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 962 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0040-4020
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๐ SIMILAR VOLUMES
## Abstract magnified image Alicyclic __N__โsubstituted 1,3โamino alcohols **13โ18** were prepared in a facile way in a oneโpot procedure from 1,3โoxazines **5โ8** in the presence of a ketone **9โ12**. The complex reaction involves palladiumโcatalyzed reduction, debenzylation and/or transimination
A diastereoselective synthesis of 1,4-amino alcohols can be achieved from a highly diastereoselective reduction of a y-keto-vinyl sulfoximine followed by C-methylation and then a highly diastereoselective palladium(0) catalysed ailylic sulfoximine to allylic sulfinamide rearrangement with 1,4-stereo