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Synthesis of alicyclic N-substituted 1,3-amino alcohols via 1,3-oxazines

✍ Scribed by Árpád Balázs; Zsolt Szakonyi; Ferenc Fülöp

Publisher: Journal of Heterocyclic Chemistry
Year: 2007
Tongue: English
Weight: 286 KB
Volume: 44
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570440219

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✦ Synopsis

Abstract

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Alicyclic N‐substituted 1,3‐amino alcohols 13‐18 were prepared in a facile way in a one‐pot procedure from 1,3‐oxazines 5‐8 in the presence of a ketone 9‐12. The complex reaction involves palladium‐catalyzed reduction, debenzylation and/or transimination and further reduction.

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