Synthesis of 1-(substituted phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydropyridine-5-carboxylic acid diethylamides as potential anti-inflammatory agents
✍ Scribed by Madhavi Gangapuram; Kinfe K. Redda
- Book ID
- 102892018
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 552 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
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Fifteen novel 1‐(substituted phenylcarbonyl/sulfonylamino)‐1,2,3,6‐tetrahydro‐ pyridine‐5‐carboxylic acid diethylamide (7, 15) were synthesized in fair to good yields via sodium borohydride reduction of the corresponding 1‐(substituted phenylcarbonyl/ sulfonylimino)‐3‐diethylcarbamoyl pyridinium ylides (6, 14) in absolute ethanol.
📜 SIMILAR VOLUMES
## Abstract Fourteen novel __N__‐(substituted phenylcarbonylamino)‐4‐ethyl‐1,2,3,6‐tetrahydropyridines **9** were synthesized in fair to good yields. 4‐Ethylpyridine **5** reacted with __O__‐mesitylenesulfonylhydroxylamine (__O__‐MSH) **4** to furnish __N__‐amino‐4‐ethylpyridinium mesitylenesulfona
## Abstract magnified image N‐Benzoylamino‐1,2,3,6‐tetrahydropyridines **9a‐q** were synthesized from 4‐substituted pyridines in four steps. Amination of pyridines was carried out to prepare intermediate N‐aminopyridinium mesylates using mesytelenesulfonyl hydroxmate (MSH) as aminating agent. N‐am