✦ LIBER ✦

Synthesis of 1-palmitoyl-2-hexadecyl-sn-glycero-3-phosphocholine (PHPC)

✍ Scribed by Richard I. Duclos Jr.

Book ID: 103042296
Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 744 KB
Volume: 66
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(93)90001-j

No coin nor oath required. For personal study only.

✦ Synopsis

A general method for the chirospecific synthesis of l-acyl-2-alkyl-sn-glycero-3-phosphocholines is described, l-Palmitoyl-2-hexadecyl-sn-glycero-3-phosphocholine (PHPC) was synthesized in 18% overall yield in ten steps via five new synthetic intermediates, and 1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine (AHPC) was also synthesized. 1-Acyl-2-alkyl-sn-glycero-3-phosphocholines, which have not been found to exist in nature, are ether lipid analogs of 1,2-diacyl-sn-glycero-3-phosphocholines, which are important components of cell membranes. Biophysical studies of hydrated bilayers of PHPC will be of interest in probing the critical importance of the central region of these amphiphilic molecules to the molecular assemblies that are formed.

📜 SIMILAR VOLUMES

Syntheses of 2H- and 13C-labeled 1,2-di-

Syntheses of 2H- and 13C-labeled 1,2-di-O-hexadecyl-sn-glycero-3-phosphoethanolamines and 1,2-di-O-hexadecyl-sn-glycero-3-phosphocholines

✍ Osama H. Abdelmageed; Richard I. Duclos Jr.; Robert G. Griffin; David J. Siminov 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 478 KB

Refolding of Carbonic Anhydrase Assisted

Refolding of Carbonic Anhydrase Assisted by 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine Liposomes

✍ Ryoichi Kuboi; Makoto Yoshimoto; Peter Walde; Pier Luigi Luisi 📂 Article 📅 1997 🏛 American Institute of Chemical Engineers 🌐 English ⚖ 166 KB

Chemo-enzymatic synthesis of 1- O-hexade

Chemo-enzymatic synthesis of 1- O-hexadecyl-2- O-palmitoyl- sn-glycerol

✍ M.L. Salto; L.E. Bertello; R.M. de Lederkremer 📂 Article 📅 1997 🏛 Springer Netherlands 🌐 English ⚖ 178 KB

Preparation of 1-O-octadecyl-2-O-methyl-

Preparation of 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine

✍ Rudolf Berchtold 📂 Article 📅 1982 🏛 Elsevier Science 🌐 English ⚖ 209 KB

The synthesis of a perdeuterated phospho

The synthesis of a perdeuterated phospholipid: 1,2-dimyristoyl-sn-glycero-3-phosphocholine-d72

✍ P.B. Kingsley; G.W. Feigenson 📂 Article 📅 1979 🏛 Elsevier Science 🌐 English ⚖ 628 KB

The synthesis of a perdeuterated phospholipid -1,2-dimyristoyl-sn-glycero-3-phosphocholine-d72 (DMPC-d72) -is described. Ordinary (protonated) DMPC was prepared by the same synthetic route and its properties were found to be the same as those of commercial DMPC. The uses of partially deuterated and

Synthesis of [32P]labelled 1-O-alkyl-2-d

Synthesis of [32P]labelled 1-O-alkyl-2-desoxy-2-amino-sn′-glycero-3-phosphocholines

✍ H. P. Deigner; B. Fyrnys 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 195 KB

## Abstract The syntheses of N‐substituted 1‐O‐alkyl‐2‐desoxy‐2‐amino‐__sn__‐glycero‐3‐[^32^P]phosphocholines were performed in four steps starting from [^32^P] POCl~3~ and the corresponding 1‐O‐alkyl‐2‐amino‐propane‐3‐ols in 5‐7% total yield.