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Synthesis of 1-Hydroxy-Substituted Pyrazolo[3,4- c ]- and Pyrazolo[4,3- c ]quinolines and -isoquinolines from 4- and 5-Aryl-Substituted 1-Benzyloxypyrazoles

✍ Scribed by Pawlas, Jan; Vedsø, Per; Jakobsen, Palle; Huusfeldt, Per Olaf; Begtrup, Mikael


Book ID
118270193
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
84 KB
Volume
65
Category
Article
ISSN
0022-3263

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Some pyrazolo[3,4-c~quinoline-4-ones 1-14 and pyrazolo[3.4-c]quinoline-I ,4-diones 15-17 were prepared and biologically evaluated for their binding at the benzodiazepine receptor (BZR) in rat cortical membranes. The moderate binding activity of 1-5,7,9-10, 13 is attributable to the lack of the optio