✦ LIBER ✦

Synthesis of [1, 6-α, α′-Diaminosuberic acid]oxytocin (‘Dicarba-oxytocin’)

✍ Scribed by Oskar Keller; Josef Rudinger

Book ID: 102252777
Publisher: John Wiley and Sons
Year: 1974
Tongue: German
Weight: 476 KB
Volume: 57
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19740570502

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Starting from a selectively protected derivative of α,α′‐diaminosuberic acid (3) the linear protected peptide 11 has been obtained. Cyclisation to 12 followed by removal of the protecting groups by hydrogenolysis afforded the ‘dicarba’ analogue of oxytocin, 1 c, which showed about 5 IU/μmol of uterotonic activity in vitro.

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