## Abstract Four isotopically labeled, metabolically stable analogs of arachidony‐lethanolamide (anandamide), an endogenous cannabinoid ligand, were synthesized via a five‐step reaction sequence starting from arachidonic acid. These stable methanandamide derivatives will serve as probes for studyin
Synthesis of [1-15N,2-13C]-labeled difloxacin
✍ Scribed by Burkhard Schmidt; Ramona Schumacher-Buffel; Brigitte Thiede; Andreas Schäffer
- Book ID
- 106214326
- Publisher
- Springer Vienna
- Year
- 2009
- Tongue
- English
- Weight
- 209 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0026-9247
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## Abstract Anandamide (Figure 1a) (arachidonyl ethanolamide, AEA), (5Z,8Z,11Z,14Z)‐N‐(2‐hydroxyethyl)‐5,8,11,14‐Eicosatetraenamide, is an endogenous cannabinoid ligand possessing important biological activity. The conformation of AEA in its native receptor binding environment is particularly of in
Labeled derivatives of N-methylolacrylamide (NMA) including 15 N-NMA, 13 C-NMA, and 13 C, 15 N-NMA were synthesized and purified. A required chemical precursor, 15 N-acrylamide, was also prepared. Reported methods for synthesizing unlabeled analogs are noted, and modifications to these methods for a