Synthesis of [1-11C]iodoethane for the preparation of [11C]ethyl labelled radiopharmaceuticals
β Scribed by G. Slegers; J. Sambre; P. Goethals; C. Vandecasteele; D. Van Haver
- Publisher
- Elsevier Science
- Year
- 1986
- Weight
- 358 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0883-2889
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A novel method for the efficient preparation of 11C-radiopharmaceuticals by on-line [11C]methylation using [11C]methyl iodide has been developed and applied to a rapid, convenient automated system. [11C]Methyl iodide is first trapped in a short column, containing an adsorber and coated substrate, wh
Starting with "CO , [carboxyl-llC1-nicotinic acid amide was synthesized via 3-p$ridyl-lithium in practically carrierfree amounts within 60 minutes. Overall radiochemical yields between 20% and 30% were obtained. Identification and purification of the labelled product was carried out by high pressure