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Synthesis, isolation, and characterization of two stereoisomeric ring sulfoxides of thioridazine

✍ Scribed by Eric C. Juenge; Clyde E. Wells; Donald E. Green; Irene S. Forrest; James N. Shoolery


Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
681 KB
Volume
72
Category
Article
ISSN
0022-3549

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A multistep synthetic route to (~)-10-[2-(1-methyl-2-piperidinyl)ethyl]-2-methylthio-lOH-phenothiazine (thioridazine) was developed which allowed for the incorporation of two deuterium atoms in the piperidine ring and a further two in the 1-position of the ethyl side chain. The key steps involved ru