Synthesis, cytotoxicity and clastogenicity of novel α-aminophosphonic acids
✍ Scribed by E. Naydenova; K. Troev; M. Topashka-Ancheva; G. Hägele; I. Ivanov; A. Kril
- Book ID
- 106221392
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 257 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0939-4451
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Synthesis of α-Substituted α-Aminophosphinic and α-Aminophosphonic Acids. -The reaction of ketoximes (I) with hypophosphorous acid affords previously unknown phosphinic acids (II), which are smoothly oxidized into the corresponding phosphonic acids (III). -(OSIPOVA, T. I.;
## Abstract The novel α‐aminophosphonic acids with hydantoin structure have been synthesized reacting 5,5‐dimetylhydantoin with formaldehyde and phosphorus trichloride, or via Kabachnik–Fields reaction. Their structures were proved by means of IR, ^1^__H__, ^13^C{^1^H}, and ^31^P NMR spectroscopy.