Synthesis, configuration, and chemical shift correlations of chiral 1,3,2-oxazaphospholidin-2-ones derived from l-serine
β Scribed by Thompson, Charles M.; Frick, Jeffrey A.; Green, Diana L. C.
- Book ID
- 118268777
- Publisher
- American Chemical Society
- Year
- 1990
- Tongue
- English
- Weight
- 847 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
In this article, we have described the asymmetric cyclization of L-serinoates and N-benzyl Lserinoate with phosphoro(no-)dichloridates or their thio-analog, respectively, and we have investigated the asymmetric induction effect of the chiral carbon center on the forming of a chiral phosphorus center
## Abstract In order to search for novel antitumor and antiviral agents with high activity and low toxicity, a series of chiral 2βthio(oxo)β1,3,2βoxazaphospholidines were synthesized via the reaction of Lβmethionol with all kinds of (thio)phosphoryl dichlorides in THF in the presence of triethylami