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Synthesis of novel chiral 2-oxo- and 2-thio-1,3,2-oxazaphospholidines via asymmetric cyclization of L-methionol with (thio)phosphoryl dichlorides

✍ Scribed by Ling-yan Liu; Ru-yu Chen; You Huang

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
102 KB
Volume
16
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

In order to search for novel antitumor and antiviral agents with high activity and low toxicity, a series of chiral 2‐thio(oxo)‐1,3,2‐oxazaphospholidines were synthesized via the reaction of L‐methionol with all kinds of (thio)phosphoryl dichlorides in THF in the presence of triethylamine at room temperature. The structures of all of the new compounds were confirmed by elemental analyses, ^1^H, ^31^P NMR, and IR spectra. Β© 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:33–38, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20060

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ChemInform Abstract: Synthesis of Chiral
ChemInform Abstract: Synthesis of Chiral 2-Oxo- and 2-Thio-1,3,2-oxazaphospholidines via the Asymmetric Cyclization of L-Serinoates with (Thio)phosphoryl Dichlorides.
✍ Zheng-Jie He; Wen-Bin Chen; Zheng-Hong Zhou; Chu-Chi Tang πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 29 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

ChemInform Abstract: Synthesis of Chiral
ChemInform Abstract: Synthesis of Chiral 2-Oxo- and 2-Thio-1,3,2-oxazaphospholidines via the Asymmetric Cyclization of L-Serinoates with (Thio)phosphoryl Dichlorides.
✍ Zheng-Jie He; Wen-Bin Chen; Zheng-Hong Zhou; Chu-Chi Tang πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons βš– 30 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v