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Synthesis, characterization, antitumor activity of nickel(II) and cobalt(II) complexes of 2,2′-diamino-4,4′-bithiazole and their interaction with dGMP

✍ Scribed by Tian Yan-Ni; Yang Pin; Li Qing-Shan; Zhao Chun-Gui

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
428 KB
Volume
14
Category
Article
ISSN
0256-7660

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✦ Synopsis

Abstract

New complexes, of bis(2,2′‐diamino‐4,4′‐bithiazole)sulfate nickel(II) and bis(2,2′‐diamino‐4,4′‐bithiazole)sulfate cobalt(II), have been prepared. The complexes were characterized by infrared and UV‐Vis spectroscopy, ^1^H NMR, elemental analyses and molar conductivity. The effect of these complexes on the DNA synthesis of sarcoma 180 cells has been studied by the technique of isotopic liquid scintillation. The results indicated that complexes show ability to inhibit DNA synthesis of the tumor cells. In order to provide a molecular basis for understanding the biological effects, the probe, trans‐en~2~Os(^2^‐H~2~)~2~ (en, ethylenediamine) as a monitor was first used to explore interaction of the complexes with 2′‐deoxyguanosine‐5′‐monophosphate (dGMP).

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