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Synthesis and Antitumor Activity of [1,2-Bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) Complexes

✍ Scribed by Ronald Gust; Rudolf Krauser; Beate Schmid; Helmut Schönenberger


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
224 KB
Volume
331
Category
Article
ISSN
0365-6233

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Enantiomerically pure 1, 2-diamino-1-(4-fluorophenyl)propanes were synthesized by stereospecific and stereoselective procedures by use of the (1R, 2S)- and (1S, 2R)-2-amino-1-(4-fluorophenyl)propanols (12a) as intermediates. The enantiomeric purity was determined by (1)H NMR spectroscopy after conve