Synthesis and Antitumor Activity of Enan
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Francois Dufrasne; Michael Gelbcke; Beate Schnurr; Ronald Gust
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Article
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2002
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John Wiley and Sons
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English
⚖ 147 KB
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Enantiomerically pure 1, 2-diamino-1-(4-fluorophenyl)propanes were synthesized by stereospecific and stereoselective procedures by use of the (1R, 2S)- and (1S, 2R)-2-amino-1-(4-fluorophenyl)propanols (12a) as intermediates. The enantiomeric purity was determined by (1)H NMR spectroscopy after conve