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Synthesis, characterization and biological activity of bis(3-Aryl-1-hexahydropyrimidinyl)methanes. Novel heterocyclic polyamine derivatives

✍ Scribed by Juan Á Bisceglia; María B. García; Rosana Massa; María L. Magri; Mariana Zani; Gabriel O. Gutkind; Liliana R. Orelli

Publisher
Journal of Heterocyclic Chemistry
Year
2004
Tongue
English
Weight
192 KB
Volume
41
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A method is described for the synthesis of bis(3‐aryl‐1‐hexahydropyrimidinyl)methanes 1, by condensation of N‐aryl‐1,3‐propanediarnines 2 with formaldehyde. The reaction mechanism involves N‐arylhexahydropyrimidines 3 as intermediates. Such compounds can also be prepared efficiently by a methylene exchange reaction between bis‐hexahydropyrimidines 1 and the corresponding diamines 2. The antimicrobial activity of compounds 1 was evaluated by the disk diffusion method and some of them showed moderate to good growth inhibition activity.

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