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ChemInform Abstract: Novel C-2 Substituted Carbapenem Derivatives. Part 1. Synthesis and Biological Activity of Non-Aromatic Heterocyclic Derivatives.

✍ Scribed by G. BURTON; N. J. C. CLEAR; A. J. EGLINGTON; A. W. GUEST; E. HUNT; A. NAYLOR; M. J. PEARSON; A. K. TAKLE

Publisher: John Wiley and Sons
Year: 2010
Weight: 35 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199725229

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✦ Synopsis

Novel C-2 Substituted Carbapenem Derivatives. Part 1. Synthesis and Biological Activity of Non-Aromatic Heterocyclic Derivatives. -A series of new carbapenems, e.g. (III), (XI), and (XIV), is investigated for biological activity. It is shown that (S)-stereochemistry at the C-2 side chain and the introduction of a double bond in the heterocycle affords better stability of these compounds to human dehydropeptidase-1 (DHP-1) besides of good activity. -(BURTON, G.; CLEAR, N.

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