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Synthesis, Characterization and Bioactivity Research of a Derivative of Secnidazole: 1-(2-Chloropropyl)-2-methyl-5-nitro-1H-imidazole

✍ Scribed by Xi-Shou Huang; Li-Sheng Wang; Yong Yin; Wan-Mei Li; Man Duan; Wei Ran; Hai-Liang Zhu


Book ID
106404852
Publisher
Springer
Year
2011
Tongue
English
Weight
369 KB
Volume
41
Category
Article
ISSN
1572-8854

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## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetic acid (**5**) which was esterified with 1‐butanol to give butyl 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetate (**8**). Reaction of the l