l-Methyl-2-nitro-1K-imidazolea carrying d i f f e r e n t 5-side chain. (iaopropyl, hydroxymethylethyl, ethenyl) have been syn- t h e b e d l a b e l l e d with I 4 C a t C2 of t h e imidazole nucleua.
Metabolism of 1-methyl-5-nitro-2-(2′ -pyrimidyl)imidazole
✍ Scribed by K. M. Baker; M. Coerezza; L. Del Corona; A. Frigerio; G. G. Massaroli; G. Sekules
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 282 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3549
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📜 SIMILAR VOLUMES
A simple four-stage conversion of 2-1nethyl-4(5>nitroimidazole to 2-methyl-4(5)-nitr0['~N""]imidazole is reported. The method consists in N-nitration of the initial compound to ?-methyl-1,4-dinitroimidazole, treating the latter with ["Nlglycine and N-dealkylation of the obtained (~-rnethyl-4-nitro[~
## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetic acid (**5**) which was esterified with 1‐butanol to give butyl 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetate (**8**). Reaction of the l