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Synthesis, characterization and anticancer activity of 3-aza-analogues of DP-7

โœ Scribed by Jalpa J. Bariwal, Manav Malhotra, Joseph Molnar, Kishor S. Jain, Anamik K. Shah, Jitender B. Bariwal


Book ID
118778066
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
411 KB
Volume
21
Category
Article
ISSN
1054-2523

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Synthesis and antitumor activity of podo
โœ Kiyoshi Tomioka; Yoshihiro Kubota; Kenji Koga ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 157 KB

## Podophyllotoxin aza-analogue 7 (3 RI =H, Rz=Me, H) was designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 5 with 3,4,5-trimethoxybenzaldehyde 6 and was found to show a promising in vitro and in vivo antitumor activity. Podophyllotoxin