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Synthesis and Antiprotozoal Activity of Aza-Analogues of Furamidine

✍ Scribed by Ismail, Mohamed A.; Brun, Reto; Easterbrook, Judy D.; Tanious, Farial A.; Wilson, W. David; Boykin, David W.


Book ID
119976674
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
122 KB
Volume
46
Category
Article
ISSN
0022-2623

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Synthesis and antitumor activity of podo
✍ Kiyoshi Tomioka; Yoshihiro Kubota; Kenji Koga πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 157 KB

## Podophyllotoxin aza-analogue 7 (3 RI =H, Rz=Me, H) was designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 5 with 3,4,5-trimethoxybenzaldehyde 6 and was found to show a promising in vitro and in vivo antitumor activity. Podophyllotoxin