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Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues

โœ Scribed by Hu, Laixing; Patel, Alpa; Bondada, Lavanya; Yang, Sihyung; Wang, Michael Zhuo; Munde, Manoj; Wilson, W. David; Wenzler, Tanja; Brun, Reto; Boykin, David W.


Book ID
121313080
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
752 KB
Volume
21
Category
Article
ISSN
0968-0896

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Synthesis and antitumor activity of podo
โœ Kiyoshi Tomioka; Yoshihiro Kubota; Kenji Koga ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 157 KB

## Podophyllotoxin aza-analogue 7 (3 RI =H, Rz=Me, H) was designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 5 with 3,4,5-trimethoxybenzaldehyde 6 and was found to show a promising in vitro and in vivo antitumor activity. Podophyllotoxin