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Synthesis and antitumor activity of podophyllotoxin aza-analogues

โœ Scribed by Kiyoshi Tomioka; Yoshihiro Kubota; Kenji Koga

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
157 KB
Volume
30
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Podophyllotoxin aza-analogue 7 (3 RI =H, Rz=Me, H) was designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 5 with 3,4,5-trimethoxybenzaldehyde 6 and was found to show a promising in vitro and in vivo antitumor activity.

Podophyllotoxin

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