Synthesis, Biological Activity, and Conformational Analysis of Four seco - d -15,19- bisnor -1α,25-Dihydroxyvitamin D Analogues, Diastereomeric at C17 and C20
✍ Scribed by Zhou, Xiaoming; Zhu, Gui-Dong; Van Haver, Dirk; Vandewalle, Maurits; De Clercq, Pierre J.; Verstuyf, Annemieke; Bouillon, Roger
- Book ID
- 126437505
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 496 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
A series of semi-rigid analogues of the hormone 1 ot,25-dihydroxyvitamin D3 have been designed in order to study the topology required for binding to the hormone receptor (VDR). The new vitamin D3 analogues 2-5 possess a rigid C17--C20 bond and minimal structural modifications on the side-chain with
## Abstract An improved synthetic route to 1α,25‐dihydroxyvitamin D~3~ des‐side chain analogues **2 a** and **2 b** with substituents at C18 is reported, along with their biological activity. These analogues display significant antiproliferative effects toward MCF‐7 breast cancer cells and prodiffe