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Synthesis, Antiviral Activity, and Mechanism of Drug Resistance of d - and l -2‘,3‘-Didehydro-2‘,3‘-dideoxy-2‘-fluorocarbocyclic Nucleosides

✍ Scribed by Wang, Jianing; Jin, Yunho; Rapp, Kimberly L.; Bennett, Matthew; Schinazi, Raymond F.; Chu, Chung K.

Book ID
120203587
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
457 KB
Volume
48
Category
Article
ISSN
0022-2623

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We have identified a selective S(N)2' reaction triggered by iodide ion that leads to the ring-opening of 2,2'-anhydro-α-nucleosides. By applying the method, we have synthesized α-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides, designed as potential antiviral agents.