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Stereoselective Synthesis and Antiviral Activity of d -2‘,3‘-Didehydro-2‘,3‘-dideoxy-2‘-fluoro-4‘-thionucleosides

✍ Scribed by Chong, Youhoon; Choo, Hyunah; Choi, Yongseok; Mathew, Judy; Schinazi, Raymond F.; Chu, Chung K.


Book ID
120444974
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
265 KB
Volume
45
Category
Article
ISSN
0022-2623

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✍ Robert J. Young; Sue Shaw-Ponter; Jamie B. Thomson; J.Allen Miller; John G. Cumm 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 325 KB

The synthesis and antiviral evaluation of 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy 4'thionucleosides in both enantiomeric series are described. Enantiomeric 4-O-silylated-4hydroxymethyl-4-thiobutyrolactones, produced in high yield from chiral glycidols, provided suitable chiral synthons: phen