Synthesis and antiviral evaluation of en
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Robert J. Young; Sue Shaw-Ponter; Jamie B. Thomson; J.Allen Miller; John G. Cumm
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Article
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1995
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Elsevier Science
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English
⚖ 325 KB
The synthesis and antiviral evaluation of 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy 4'thionucleosides in both enantiomeric series are described. Enantiomeric 4-O-silylated-4hydroxymethyl-4-thiobutyrolactones, produced in high yield from chiral glycidols, provided suitable chiral synthons: phen